Manchester United vs Tottenham: Premier League - LIVE
Players have been falling like flies with their respective injury concerns throughout the four-game international break, and both sides have suffered here in that respect. United were left sweating over talisman and captain Bruno Fernandes, while Spurs were worried about Dutch defensive duo Jan Paul van Hecke and Micky van de Ven after their respective knocks with their country.
Both teams will be looking for marked improvements to their starts to the new campaign, as Roberto De Zerbi's men sit bottom of the league table after five games. Michael Carrick's hosts are in 12th position after a stuttering opening run that has seen them lose to newly-promoted Hull City, be held by Everton, lose the Manchester derby, and be knocked out prematurely in the Carabao Cup.
Keep up to date with all the latest from Old Trafford with our live blog below, with insight and analysis from Oli Gent and Sam Tabuteau. It remains to be seen, however, how their respective injury problems will hurt them.
Both need a win to kickstart their campaigns, but for who, Chris Kamara? Tottenham team news Van Hecke and Van de Ven suffered foot and hand injuries, respectively, while on international duty with the Netherlands.
Dejan Kulusevski is closing in on a return to action after more than 500 days out injured with a complicated patella injury that has required two separate surgeries. The same is true of Amad Diallo, who is yet to feature for United this season.
Elsewhere, Matthijs de Ligt is thought to be closing in on a return from his long-standing back injury, but Carrick gave no assurances as to his availability this weekend. Patrick Dorgu and Noussair Mazraoui were both victims of the international break, with the former suffering a hamstring injury and the latter, a knock.
Benjamin Sesko is facing weeks on the sidelines with a shin injury. to Standard Sport's live coverage of Tottenham's visit to Old Trafford.
Two struggling giants at the start of the new season. Who will come out on top?
Stay tuned for all the updates, with kick off at 5.30pm BST.